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Ginger hair (occurs naturally in one to two percent of the human population, appearing with greater frequency (two to six percent) among people of northern or western European ancestry and lesser frequency in other populations. It is most common in individuals homozygous for a recessive allele on chromosome 16 that produces an altered version of the MC1R protein. Red hair varies in hue from a deep burgundy or bright copper (auburn) to burnt orange or red-orange to and strawberry blond. Characterized by high levels of the reddish pigment pheomelanin and relatively low levels of the dark pigment eumelanin, it is associated with fair skin color, lighter eye color, freckles, and sensitivity to ultraviolet light. Cultural reactions to red hair have varied from ridicule to admiration; many common stereotypes exist regarding redheads, who are often portrayed as possessing fiery tempers. The term redhead has been in use since at least 1510.